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KMID : 0984920090110020123
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Journal of Skin Barrier Research
2009 Volume.11 No. 2 p.123 ~ p.123
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Potential role of TRPV5 in the formation of epidermal calcium gradients and the epidermal permeability barrier
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Kim Hyun-Jung
Jeong Se-Kyoo
Kim Ji-Min
Jeong Min-Kyung
Lee Seung-Hun
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Abstract
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TRPV5 and 6, which belong to the superfamily of transient receptor potential channels, constitute the apical Ca2+ entry mechanism in active Ca2+ transport in kidney and intestine. Considering the calcium gradient in viable epidermis, it is interesting that the extracellular calcium ion at the SG-SC junction is abruptly disappeared. Currently, it is unclear which
receptors or ion channels are underlying the acute loss of calcium ions at SG-SC junction. In this study, we have investigated the potential role of TRPV5 and 6 in the regulation of epidermal calcium ion concentration. Firstly, epidermal expressions of TRPV5 and 6 were observed in the suprabasal layer of normal skin, whereas in the lesional skin of atopic dermatitis and psoriasis, epidermal expression of TRPV5 and 6 were lost. Treatments of psoriasis, however, resulted
in the re-appearance of TRPV5 and 6 expressions in epidermis. In an animal model, acute disruption of epidermal permeability barrier induced the decrease of TRPV 5 and 6 expressions, and the recovery of those proteins was parallel to that of calcium gradient. The occlusion after barrier disruption, which inhibits the recovery of calcium gradient, also inhibited TRPV5 and 6 expressions. These results suggested that TRPV5 and 6 are closely related with the epidermal
calcium gradient. Since the extracellular pH environment regulates the expressions of TRPV5 and 6, it can be suggested that TRPV5 and 6 are potential sensor for pH environment, which controls calcium movement and keratinocyte differentiation.
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KEYWORD
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TRPV 5, TRPV 6, Keratinocyte differentiation, Epidermal calcium gradient, Skin pH
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